Journal: American Journal of Cancer Research
Article Title: Regulating TKT activity inhibits proliferation of human acute lymphoblastic leukemia cells
doi:
Figure Lengend Snippet: KEGG pathway graph rendered by Pathview and GSEA enrichment plots. KEGG Pathview showing pentose phosphate pathway genes up or down regulated in (A) niclosamide (2 mM; 24 h) treated CCRF-CEM cells compared to WT CCRF-CEM cells. In (A), enzyme 2.2.1.1: transketolase; enzyme 2.2.1.2: transaldolase; enzyme: 1.1.1.49: G6PD. (B) GSEA enrichment plots of the HALLMARK PENTOSE PHOSPHATE PATHWAY and the corresponding heat map for control versus niclosamide (2 mM) treatment groups in CCRF-CEM cells. Transaldolase: TALDO1; Transketolase: TKT. G6PD: Glucose 6 phosphate dehydrogenase.
Article Snippet: KEGG autophagy pathway graph rendered by Pathview revealed down-regulated genes (in green), such as LC3 and p62 ( ) that are involved in the autophagic pathway in T-ALL patients’ PBMC samples when compared with healthy controls.
Techniques: Control